Reciprocal control of T helper cell and dendritic cell differentiation
MC Rissoan, V Soumelis, N Kadowaki, G Grouard… - Science, 1999 - science.org
MC Rissoan, V Soumelis, N Kadowaki, G Grouard, F Briere, RW Malefyt, YJ Liu
Science, 1999•science.orgIt is not known whether subsets of dendritic cells provide different cytokine
microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2
cells. Human monocyte (pDC1)–derived dendritic cells (DC1) were found to induce TH1
differentiation, whereas dendritic cells (DC2) derived from CD4+ CD3–CD11c–plasmacytoid
cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4
(IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect …
microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2
cells. Human monocyte (pDC1)–derived dendritic cells (DC1) were found to induce TH1
differentiation, whereas dendritic cells (DC2) derived from CD4+ CD3–CD11c–plasmacytoid
cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4
(IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect …
It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)–derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+CD3–CD11c–plasmacytoid cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-γ. Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.
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