An activated CD8+ T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status
AL Landay, CE Mackewicz, JA Levy - Clinical immunology and …, 1993 - Elsevier
We have examined the relation of cell surface marker phenotype to the anti-human
immunodeficiency virus (HIV) function of CD8+ cells from individuals at various clinical
stages of HIV infection. Multiparametric flow cytometry analysis demonstrated that the most
significant changes in cell surface phenotype was found within the CD8+ cell subset
expressing HLA-DR and CD28. These changes in the levels of CD28 and HLA-DR
expression on CD8+ cells were found to be related to antiviral activity and have clinical …
immunodeficiency virus (HIV) function of CD8+ cells from individuals at various clinical
stages of HIV infection. Multiparametric flow cytometry analysis demonstrated that the most
significant changes in cell surface phenotype was found within the CD8+ cell subset
expressing HLA-DR and CD28. These changes in the levels of CD28 and HLA-DR
expression on CD8+ cells were found to be related to antiviral activity and have clinical …