Decreased expression of the cystic fibrosis transmembrane conductance regulator protein in remodeled airway epithelium from lung transplanted patients
S Brézillon, H Hamm, M Heilmann, HJ Schafers… - Human pathology, 1997 - Elsevier
The absence or mislocalization of cystic fibrosis transmembrane conductance regulator
(CFTR) is regarded as being specific for cystic fibrosis (CF). In principle, the supply of a non-
CF lung transplant to a CF patient should bring up normal CFTR expression in the lower
airways. Immunolocalization of CFTR and of epithelial differentiation markers (ie,
cytokeratins 13, 14, and 18, and desmoplakins 1 and 2) was carried out on 21 mucosal
biopsies from the upper lobe of grafts in non-CF (n= 12) and CF patients (n= 9) retrieved …
(CFTR) is regarded as being specific for cystic fibrosis (CF). In principle, the supply of a non-
CF lung transplant to a CF patient should bring up normal CFTR expression in the lower
airways. Immunolocalization of CFTR and of epithelial differentiation markers (ie,
cytokeratins 13, 14, and 18, and desmoplakins 1 and 2) was carried out on 21 mucosal
biopsies from the upper lobe of grafts in non-CF (n= 12) and CF patients (n= 9) retrieved …