The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats
FY Lee, A Albillos, LA Colombato, RJ Groszmann - Hepatology, 1992 - journals.lww.com
This study examined whether an increased activity of the endothelium–derived relaxing
factor, nitric oxide, may account for the hyporesponsiveness to vasoconstrictors in portal
hypertension. We performed dose–response curves to methoxamine, an α–adrenoceptor
agonist, with and without N ω–nitro–L–arginine, a specific inhibitor of nitric oxide synthesis,
in experimental portal hypertension. Partial portal vein—ligated or sham–operated rats were
pretreated with a continuous intravenous infusion of either N ω–nitro–L–arginine (50 μgˇ kg …
factor, nitric oxide, may account for the hyporesponsiveness to vasoconstrictors in portal
hypertension. We performed dose–response curves to methoxamine, an α–adrenoceptor
agonist, with and without N ω–nitro–L–arginine, a specific inhibitor of nitric oxide synthesis,
in experimental portal hypertension. Partial portal vein—ligated or sham–operated rats were
pretreated with a continuous intravenous infusion of either N ω–nitro–L–arginine (50 μgˇ kg …