Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
V Haroutunian, DP Perl, DP Purohit, D Marin… - Archives of …, 1998 - jamanetwork.com
Background Identification of the neuropathological lesions that are most closely associated
with the earliest symptoms of Alzheimer disease (AD) is crucial to the understanding of the
disease process and the development of treatment strategies to affect its progress. Do the
classical neuropathological lesions of AD precede, follow, or occur in synchrony with the
earliest signs of cognitive deterioration? Design and Outcome Measures We examined the
extent of neuritic plaque (NP) formation in 5 neocortical regions and the hippocampus …
with the earliest symptoms of Alzheimer disease (AD) is crucial to the understanding of the
disease process and the development of treatment strategies to affect its progress. Do the
classical neuropathological lesions of AD precede, follow, or occur in synchrony with the
earliest signs of cognitive deterioration? Design and Outcome Measures We examined the
extent of neuritic plaque (NP) formation in 5 neocortical regions and the hippocampus …