Recent data on the roles of vesicle-and 'raft '-mediated pathways in intracellular free
cholesterol (FC) transport are reviewed. Cholesterol internalized from plasma lipoproteins is
transferred via endocytic vesicles to the trans-Golgi network (TGN), consistent with prior data
indicating a key role for this organelle in protein and lipid sorting and transport. Newly
synthesized and lipoprotein-derived FC are returned to the cell surface by a common raft-
dependent pathway. Intracellular FC transport promotes the delivery of GPI-anchored …