Control of inflammation, cytokine expression, and germinal center formation by BCL-6

AL Dent, AL Shaffer, X Yu, D Allman, LM Staudt - Science, 1997 - science.org
AL Dent, AL Shaffer, X Yu, D Allman, LM Staudt
Science, 1997science.org
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and
mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed
myocarditis and pulmonary vasculitis, had no germinal centers, and had increased
expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled
sites bound by the STAT (signal transducers and activators of transcription) transcription
factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)–induced …
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription) transcription factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)–induced transcription when bound to a site recognized by the IL-4–responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6–deficient mice and participate in lymphoid malignancies.
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