[HTML][HTML] Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements (∗)

MD Siegel, DH Zhang, P Ray, A Ray - Journal of Biological Chemistry, 1995 - ASBMB
Interleukin-5 (IL-5) plays a central role in the growth and differentiation of eosinophils and
contributes to several disease states including asthma. Accumulating evidence suggests a
role for cAMP as an immunomodulator; agents that increase intracellular cAMP levels have
been shown to inhibit production of cytokines predominantly produced by T helper (Th) 1
cells such as IL-2 and interferon γ (IFN-γ). In contrast, the production of IL-5, predominantly
produced by Th2 cells, is actually enhanced by these agents. In this report, we have …