[HTML][HTML] Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response
X Wang, TL Yue, EH Ohlstein, CP Sung… - Journal of Biological …, 1996 - ASBMB
Interferon-inducible protein-10 (IP-10) is a member of the CXC chemokine family. Using
mRNA differential display, we isolated a rat homologue to murine and human IP-10 from
lipopolysaccharide-stimulated carotid arteries. Our studies demonstrated that IP-10 is a
potent mitogenic and chemotactic factor for vascular smooth muscle cells, the critical
features of smooth muscle cells for their contribution to the pathogenesis of atherosclerosis
and restenosis. IP-10 induced a concentrationdependent stimulation of DNA synthesis, cell …
mRNA differential display, we isolated a rat homologue to murine and human IP-10 from
lipopolysaccharide-stimulated carotid arteries. Our studies demonstrated that IP-10 is a
potent mitogenic and chemotactic factor for vascular smooth muscle cells, the critical
features of smooth muscle cells for their contribution to the pathogenesis of atherosclerosis
and restenosis. IP-10 induced a concentrationdependent stimulation of DNA synthesis, cell …