[HTML][HTML] Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells
AD Schecter, BJ Rollins, YJ Zhang, IF Charo… - Journal of Biological …, 1997 - ASBMB
Monocyte chemoattractant protein-1 (MCP-1) is a CC chemokine thought to play a major
role in recruiting monocytes to the atherosclerotic plaque. Tissue factor (TF), the initiator of
coagulation, is found in the atherosclerotic plaque, macrophages, and human aortic smooth
muscle cells (SMC). The exposure of TF during plaque rupture likely induces acute
thrombosis, leading to myocardial infarction and stroke. This report demonstrates that MCP-
1 induces the accumulation of TF mRNA and protein in SMC and in THP-1 myelomonocytic …
role in recruiting monocytes to the atherosclerotic plaque. Tissue factor (TF), the initiator of
coagulation, is found in the atherosclerotic plaque, macrophages, and human aortic smooth
muscle cells (SMC). The exposure of TF during plaque rupture likely induces acute
thrombosis, leading to myocardial infarction and stroke. This report demonstrates that MCP-
1 induces the accumulation of TF mRNA and protein in SMC and in THP-1 myelomonocytic …