The role of the T cell receptor in positive and negative selection of developing T cells
M Blackman, J Kappler, P Marrack - Science, 1990 - science.org
M Blackman, J Kappler, P Marrack
Science, 1990•science.orgAlthough many combinations of αβ T cell receptors are available to the T cells in any given
organism, far fewer are actually used by mature T cells. The combinations used are limited
by two selective processes, positive selection of T cells bearing receptors that will be useful
to the host, and clonal elimination or inactivation of T cells bearing receptors that will be
damaging to the host. The ways in which these two apparently contradictory processes
occur, and the hypotheses that have been suggested to reconcile them, are discussed.
organism, far fewer are actually used by mature T cells. The combinations used are limited
by two selective processes, positive selection of T cells bearing receptors that will be useful
to the host, and clonal elimination or inactivation of T cells bearing receptors that will be
damaging to the host. The ways in which these two apparently contradictory processes
occur, and the hypotheses that have been suggested to reconcile them, are discussed.
Although many combinations of αβ T cell receptors are available to the T cells in any given organism, far fewer are actually used by mature T cells. The combinations used are limited by two selective processes, positive selection of T cells bearing receptors that will be useful to the host, and clonal elimination or inactivation of T cells bearing receptors that will be damaging to the host. The ways in which these two apparently contradictory processes occur, and the hypotheses that have been suggested to reconcile them, are discussed.
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