[CITATION][C] Inhaled nitric oxide in sickle cell disease with acute chest syndrome
AM Atz, DL Wessel - The Journal of the American Society of …, 1997 - pubs.asahq.org
The acute chest syndrome (ACS), characterized by fever, chest pain, and radiographic
evidence of new pulmonary infiltrate, effusion, or edema in patients with sickle cell disease
is a significant cause of morbidity and death.[1] The often rapid resolution of severe ACS
after exchange transfusion suggests that pulmonary vascular occlusion and ischemia and
infarction play an important pathophysiologic role regardless of the etiology.[2] Recent
appreciation of the importance of interactions between sickle erythrocytes and vascular …
evidence of new pulmonary infiltrate, effusion, or edema in patients with sickle cell disease
is a significant cause of morbidity and death.[1] The often rapid resolution of severe ACS
after exchange transfusion suggests that pulmonary vascular occlusion and ischemia and
infarction play an important pathophysiologic role regardless of the etiology.[2] Recent
appreciation of the importance of interactions between sickle erythrocytes and vascular …