Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations
DG Marsh, JD Neely, DR Breazeale, B Ghosh… - Science, 1994 - science.org
DG Marsh, JD Neely, DR Breazeale, B Ghosh, LR Freidhoff, E Ehrlich-Kautzky, C Schou…
Science, 1994•science.orgSib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of
five markers in chromosome 5q31. 1 with a gene controlling total serum immunoglobulin E
(IgE) concentration. No linkage was found between these markers and specific IgE antibody
concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs
confirmed evidence for linkage to 5q31. 1, especially to the interleukin-4 gene (IL4). A
combination of segregation and maximum likelihood analyses provided further evidence for …
five markers in chromosome 5q31. 1 with a gene controlling total serum immunoglobulin E
(IgE) concentration. No linkage was found between these markers and specific IgE antibody
concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs
confirmed evidence for linkage to 5q31. 1, especially to the interleukin-4 gene (IL4). A
combination of segregation and maximum likelihood analyses provided further evidence for …
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.
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