[HTML][HTML] Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation
AD Kohn, F Takeuchi, RA Roth - Journal of Biological Chemistry, 1996 - ASBMB
Akt is a serine/threonine kinase that is stimulated by receptor tyrosine kinases and contains
a pleckstrin homology domain. One model proposed to explain this activation suggests that
receptor tyrosine kinases stimulate a phosphatidylinositol 3-kinase whose lipid products
directly activate Akt kinase by interacting with its pleckstrin homology domain. In the present
study, we show, in three cell types, that Akt does not require its pleckstrin homology domain
to respond to either insulin or platelet-derived growth factor. Moreover, attachment of the src …
a pleckstrin homology domain. One model proposed to explain this activation suggests that
receptor tyrosine kinases stimulate a phosphatidylinositol 3-kinase whose lipid products
directly activate Akt kinase by interacting with its pleckstrin homology domain. In the present
study, we show, in three cell types, that Akt does not require its pleckstrin homology domain
to respond to either insulin or platelet-derived growth factor. Moreover, attachment of the src …