[HTML][HTML] Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β-adrenergic agonists in rat epididymal fat cells: activation of protein kinase B …
SK Moule, GI Welsh, NJ Edgell, EJ Foulstone… - Journal of Biological …, 1997 - ASBMB
Previous studies using L6 myotubes have suggested that glycogen synthase kinase-3 (GSK-
3) is phosphorylated and inactivated in response to insulin by protein kinase B (PKB, also
known as Akt or RAC)(Cross, DAE, Alessi, DR, Cohen, P., Andjelkovic, M., and Hemmings,
BA (1995) Nature 378, 785-789). In the present study, marked increases in the activity of
PKB have been shown to occur in insulin-treated rat epididymal fat cells with a time course
compatible with the observed decrease in GSK-3 activity. Isoproterenol, acting primarily …
3) is phosphorylated and inactivated in response to insulin by protein kinase B (PKB, also
known as Akt or RAC)(Cross, DAE, Alessi, DR, Cohen, P., Andjelkovic, M., and Hemmings,
BA (1995) Nature 378, 785-789). In the present study, marked increases in the activity of
PKB have been shown to occur in insulin-treated rat epididymal fat cells with a time course
compatible with the observed decrease in GSK-3 activity. Isoproterenol, acting primarily …