CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+ T Cells: Role of signal transduction
A Kinter, A Catanzaro, JA Monaco… - Proceedings of the …, 1998 - National Acad Sciences
A Kinter, A Catanzaro, JA Monaco, M Ruiz, J Justement, S Moir, J Arthos, A Oliva, L Ehler…
Proceedings of the National Academy of Sciences, 1998•National Acad SciencesThis study demonstrates that several CC-chemokines, including those that inhibit entry and
replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic
strains in CD4+ T cells. Enhancement of T-tropic HIV replication is observed at early stages
of replication, requires signaling through inhibitory guanine nucleotide-binding regulatory
(Gi) proteins, and is associated with increased cell surface colocalization of CD4 and the T-
tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors …
replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic
strains in CD4+ T cells. Enhancement of T-tropic HIV replication is observed at early stages
of replication, requires signaling through inhibitory guanine nucleotide-binding regulatory
(Gi) proteins, and is associated with increased cell surface colocalization of CD4 and the T-
tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors …
This study demonstrates that several CC-chemokines, including those that inhibit entry and replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic strains in CD4+ T cells. Enhancement of T-tropic HIV replication is observed at early stages of replication, requires signaling through inhibitory guanine nucleotide-binding regulatory (Gi) proteins, and is associated with increased cell surface colocalization of CD4 and the T-tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors that influence the replication and spread of T-tropic strains of HIV in vivo and suggest that the use of cell signaling CC-chemokines as therapeutic agents for the purpose of limiting HIV replication in vivo should be approached with caution.
National Acad Sciences
