Publisher Summary This chapter updates information on the coupling among
hyperglycemia, intra and extracellular acidosis and brain damage because of ischemia or
hypoxia, and discusses cellular and molecular mechanisms that may be involved. When
ischemia is complicated by excessive acidosis, the ischemic damage encompasses post-
ischemic seizures, edema, and pannecrosis. The cellular and molecular mechanisms
responsible for these alterations have not been adequately defined. However, it seems likely …