Clathrin, adaptors, and sorting
BMF Pearse, MS Robinson - Annual review of cell biology, 1990 - annualreviews.org
BMF Pearse, MS Robinson
Annual review of cell biology, 1990•annualreviews.orgIn eukaryotic cells, newly synthesized protein for export is made in the rough endoplasmic
reticulum and then processed and packaged during passage through an elaborate series of
specialized membrane-bound com partments (Palade 1975). How are proteins distributed to
their correct locations among these membrane compartments? A non-selective bulk flow to
the cell surface exists (eg Sabatini et a11982; Pfeffer & Rothman 1987), while a small
number of sorting labels have been identified on lumenal proteins, which diverts them from …
reticulum and then processed and packaged during passage through an elaborate series of
specialized membrane-bound com partments (Palade 1975). How are proteins distributed to
their correct locations among these membrane compartments? A non-selective bulk flow to
the cell surface exists (eg Sabatini et a11982; Pfeffer & Rothman 1987), while a small
number of sorting labels have been identified on lumenal proteins, which diverts them from …
In eukaryotic cells, newly synthesized protein for export is made in the rough endoplasmic reticulum and then processed and packaged during passage through an elaborate series of specialized membrane-bound com partments (Palade 1975). How are proteins distributed to their correct locations among these membrane compartments? A non-selective bulk flow to the cell surface exists (eg Sabatini et a11982; Pfeffer & Rothman 1987), while a small number of sorting labels have been identified on lumenal proteins, which diverts them from this flow. For example, the
Annual Reviews