Although ischemia-reperfusion of mouse kidney is known to cause severe renal failure due
to tubular cell death, the exact cellular mechanism responsible for this phenomenon is not
clear. To investigate the spatial and temporal development of renal cell death and the role of
Fas/APO-1/CD95 (Fas) in this process, the left renal vessels were occluded in a group of
mice for 30, 60, or 120 min followed by reperfusion for 24 h (n= 4 for each group). Analysis of
the isolated DNA in agarose-gel electrophoresis revealed a typical ladder pattern of bands …