[HTML][HTML] Both cellular and soluble forms of thrombomodulin inhibit fibrinolysis by potentiating the activation of thrombin-activable fibrinolysis inhibitor
L Bajzar, M Nesheim, J Morser, PB Tracy - Journal of Biological Chemistry, 1998 - ASBMB
Thrombin-activable fibrinolysis inhibitor (TAFI) is a recently described plasma zymogen that
can be activated by thrombin to an enzyme with carboxypeptidase B-like activity. The
enzyme, TAFIa, potently attentuates fibrinolysis. TAFI activation, like protein C activation, is
augmented about 1250-fold by thrombomodulin (TM). In this work, the effects of both soluble
and cellular forms of TM on TAFI activation-dependent suppression of fibrinolysis were
investigated. Soluble TM included in clots formed from purified components, barium citrate …
can be activated by thrombin to an enzyme with carboxypeptidase B-like activity. The
enzyme, TAFIa, potently attentuates fibrinolysis. TAFI activation, like protein C activation, is
augmented about 1250-fold by thrombomodulin (TM). In this work, the effects of both soluble
and cellular forms of TM on TAFI activation-dependent suppression of fibrinolysis were
investigated. Soluble TM included in clots formed from purified components, barium citrate …