Increased release of prostaglandins from the mesenteric vascular bed of diabetic animals: the effects of glucose and insulin
K Fujii, M Soma, YS Huang, MS Manku… - Prostaglandins …, 1986 - Elsevier
To study prostaglandin (PG) metabolism in peripheral vascular beds, PGs and TxB 2
released from perfused mesenteric tissues were measured in both normal and
streptozotocin (STZ)-induced diabetic rats. The release of 6-keto-prostaglandin F 1α (6-keto-
PGF 1α), thromboxane B 2 (TxB 2) and prostaglandin E 2 (PGE 2) was significantly
increased in mesenteric vascular beds from diabetics in comparison with control rats. The 6-
keto-PGF 1α/TxB 2 ratio was decreased in diabetics. In order to clarify the mechanism of this …
released from perfused mesenteric tissues were measured in both normal and
streptozotocin (STZ)-induced diabetic rats. The release of 6-keto-prostaglandin F 1α (6-keto-
PGF 1α), thromboxane B 2 (TxB 2) and prostaglandin E 2 (PGE 2) was significantly
increased in mesenteric vascular beds from diabetics in comparison with control rats. The 6-
keto-PGF 1α/TxB 2 ratio was decreased in diabetics. In order to clarify the mechanism of this …