Genetics of insulin-dependent diabetes; non-major histocompatibility genes
TR Merriman, JA Todd - Hormone and metabolic research, 1996 - thieme-connect.com
Hormone and metabolic research, 1996•thieme-connect.com
Recently, the major advances in understanding the genetics of type 1 diabetes have come
using the positional cloning approach, both in mouse and human. Construction of congenic
mouse strains and, in human, the exploitation of linkage disequilibrium between very closely
linked markers and disease-predisposing loci, is enabling fine mapping of these loci.
using the positional cloning approach, both in mouse and human. Construction of congenic
mouse strains and, in human, the exploitation of linkage disequilibrium between very closely
linked markers and disease-predisposing loci, is enabling fine mapping of these loci.
Abstract
Recently, the major advances in understanding the genetics of type 1 diabetes have come using the positional cloning approach, both in mouse and human. Construction of congenic mouse strains and, in human, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.
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