[HTML][HTML] Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
M Adams, MJ Reginato, D Shao, MA Lazar… - Journal of Biological …, 1997 - ASBMB
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) regulates
transcription in response to prostanoid and thiazolidinedione ligands and promotes
adipocyte differentiation. The amino-terminal A/B domain of this receptor contains a
consensus mitogen-activated protein kinase site in a region common to PPARγ1 and-γ2
isoforms. The A/B domain of human PPARγ1 was phosphorylated in vivo, and this was
abolished either by mutation of serine 84 to alanine (S84A) or coexpression of a …
transcription in response to prostanoid and thiazolidinedione ligands and promotes
adipocyte differentiation. The amino-terminal A/B domain of this receptor contains a
consensus mitogen-activated protein kinase site in a region common to PPARγ1 and-γ2
isoforms. The A/B domain of human PPARγ1 was phosphorylated in vivo, and this was
abolished either by mutation of serine 84 to alanine (S84A) or coexpression of a …