Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
regulate gene transcription in response to peroxisome proliferators and fatty acids. PPARs
also play an important role in the regulation of adipocyte differentiation. It is unclear,
however, what naturally occurring compounds activate each of the PPAR subtypes. To
address this issue, a screening assay was established using heterologous fusions of the
bacterial tetracycline repressor to several members of the peroxisome proliferator-activated …