The effect of nedocromil sodium on the early and late reaction and allergen-induced bronchial hyperresponsiveness
R Aalbers, HF Kauffman, H Groen, GH Koëter… - Journal of allergy and …, 1991 - Elsevier
Bronchial hyperresponsiveness (BHR) to methacholine was studied in 14 patients with
asthma and five healthy control subjects, with and without pretreatment with nedocromil
sodium, 3 and 24 hours after allergen challenge. Eleven patients demonstrated a dual
asthmatic response. A significant decrease in the provocative concentration causing a 20%
fall in FEV 1 was found from a geometric mean starting value of 1.18 mg/ml on the control
day to 0.24 mg/ml (p< 0.001) and to 0.17 mg/ml (p< 0.007) 3 and 24 hours after allergen …
asthma and five healthy control subjects, with and without pretreatment with nedocromil
sodium, 3 and 24 hours after allergen challenge. Eleven patients demonstrated a dual
asthmatic response. A significant decrease in the provocative concentration causing a 20%
fall in FEV 1 was found from a geometric mean starting value of 1.18 mg/ml on the control
day to 0.24 mg/ml (p< 0.001) and to 0.17 mg/ml (p< 0.007) 3 and 24 hours after allergen …