[HTML][HTML] Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and …
FX Zhang, CJ Kirschning, R Mancinelli, XP Xu… - Journal of Biological …, 1999 - ASBMB
Bacterial lipopolysaccharide (LPS)-mediated immune responses, including activation of
monocytes, macrophages, and endothelial cells, play an important role in the pathogenesis
of Gram-negative bacteria-induced sepsis syndrome. Activation of NF-κB is thought to be
required for cytokine release from LPS-responsive cells, a critical step for endotoxic effects.
Here we investigated the role and involvement of interleukin-1 (IL-1) and tumor necrosis
factor (TNF-α) signal transducer molecules in LPS signaling in human dermal microvessel …
monocytes, macrophages, and endothelial cells, play an important role in the pathogenesis
of Gram-negative bacteria-induced sepsis syndrome. Activation of NF-κB is thought to be
required for cytokine release from LPS-responsive cells, a critical step for endotoxic effects.
Here we investigated the role and involvement of interleukin-1 (IL-1) and tumor necrosis
factor (TNF-α) signal transducer molecules in LPS signaling in human dermal microvessel …