[HTML][HTML] Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene
BS Taylor, ME De Vera, RW Ganster, Q Wang… - Journal of biological …, 1998 - ASBMB
The human inducible nitric oxide synthase (iNOS) gene is overexpressed in a number of
human inflammatory diseases. Previously, we observed that the human iNOS gene is
transcriptionally regulated by cytokines and demonstrated that the cytokine-responsive
regions are upstream of− 3.8 kilobase pairs (kb). Therefore, the purpose of this study was to
further localize the functional enhancer elements and to assess the role of the transcription
factor NF-κB in both human liver (AKN-1) and human lung (A549) epithelial cell lines. The …
human inflammatory diseases. Previously, we observed that the human iNOS gene is
transcriptionally regulated by cytokines and demonstrated that the cytokine-responsive
regions are upstream of− 3.8 kilobase pairs (kb). Therefore, the purpose of this study was to
further localize the functional enhancer elements and to assess the role of the transcription
factor NF-κB in both human liver (AKN-1) and human lung (A549) epithelial cell lines. The …