[CITATION][C] Which guesstimate is the best guesstimate? Predicting chemotherapeutic outcomes
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NEWS & VIEWS mors the xenograft assay could be used to derive more effective cancer
therapies. Furthermore, they propose that the difference in sensitivity observed in nude mice
might reflect the beneficial effects of a "feeder layer" of metabolically active but non-dividing
p21 * cells. In other words, the p21 ''' cells that appear to be "killed" by radiation do not …
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NEWS & VIEWS mors the xenograft assay could be used to derive more effective cancer
therapies. Furthermore, they propose that the difference in sensitivity observed in nude mice
might reflect the beneficial effects of a "feeder layer" of metabolically active but non-dividing
p21 * cells. In other words, the p21 ''' cells that appear to be "killed" by radiation do not …
Assays that distinguish between cell cycle arrest and apoptosis should help to determine the response of tumor cells to chemotherapy in the clinic (pages 1034–1036).
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