[HTML][HTML] Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification: ROLE OF THE Na+/H+-ANTIPORT (∗)
J Li, A Eastman - Journal of Biological Chemistry, 1995 - ASBMB
Apoptosis is a form of cell death associated with DNA fragmentation and chromatin
condensation. We recently established that intracellular acidification occurred during
apoptosis following cytotoxic insult. The current studies were designed to determine whether
intracellular acidification was more generally associated with apoptosis, specifically in a
model of growth factor withdrawal. Upon withdrawal of interleukin-2, CTLL-2 cells
accumulated in the G 1 phase of the cell cycle and started to fragment their DNA around 12 …
condensation. We recently established that intracellular acidification occurred during
apoptosis following cytotoxic insult. The current studies were designed to determine whether
intracellular acidification was more generally associated with apoptosis, specifically in a
model of growth factor withdrawal. Upon withdrawal of interleukin-2, CTLL-2 cells
accumulated in the G 1 phase of the cell cycle and started to fragment their DNA around 12 …