Fatal reactivation of precore mutant hepatitis B virus associated with fibrosing cholestatic hepatitis after bone marrow transplantation
C McIvor, J Morton, A Bryant, WG Cooksley… - Annals of internal …, 1994 - acpjournals.org
C McIvor, J Morton, A Bryant, WG Cooksley, S Durrant, N Walker
Annals of internal medicine, 1994•acpjournals.orgLiver failure caused by reactivation of hepatitis B virus (HBV) is an uncommon complication
of bone marrow transplantation [1-3]. Fibrosing cholestatic hepatitis is a recently described
liver lesion that develops after liver transplantation for chronic HBV infection. Hepatitis B
virus precore mutant infection has been associated with liver failure after cytotoxic
chemotherapy [4] and with fibrosing cholestatic hepatitis after liver transplantation [5, 6], but
the relation is unclear. We describe a patient who developed fibrosing cholestatic hepatitis …
of bone marrow transplantation [1-3]. Fibrosing cholestatic hepatitis is a recently described
liver lesion that develops after liver transplantation for chronic HBV infection. Hepatitis B
virus precore mutant infection has been associated with liver failure after cytotoxic
chemotherapy [4] and with fibrosing cholestatic hepatitis after liver transplantation [5, 6], but
the relation is unclear. We describe a patient who developed fibrosing cholestatic hepatitis …
Liver failure caused by reactivation of hepatitis B virus (HBV) is an uncommon complication of bone marrow transplantation [1-3]. Fibrosing cholestatic hepatitis is a recently described liver lesion that develops after liver transplantation for chronic HBV infection. Hepatitis B virus precore mutant infection has been associated with liver failure after cytotoxic chemotherapy [4] and with fibrosing cholestatic hepatitis after liver transplantation [5, 6], but the relation is unclear. We describe a patient who developed fibrosing cholestatic hepatitis and HBV precore mutant infection after bone marrow transplantation.
acpjournals.org