Effect of proteases and other treatments on the proliferative assembly of tight junction strands in the rat prostate tissue

HW Meyer, C Freytag, T Freytag, W Richter - Experimental Pathology, 1988 - Elsevier
As already observed with the freeze-fracture technique by KACHAR and PINTO DA SILVA
(1981) incubation of excised rat ventral prostate tissue at 37° C results in proliferation of tight
junction strands over the lateral membranes of the epithelial cells, an effect not occurring
after incubation at 4° C. Our investigations have shown that a pretreatment with protease
inhibitor Contrykal® at 4 oc suppresses the proliferation of tight junction strands at 37° C. On
the other hand the added proteases trypsin and pronase induce the proliferation already at …