Identification of a monoclonal antibody specific for a murine T3 polypeptide.
O Leo, M Foo, DH Sachs… - Proceedings of the …, 1987 - National Acad Sciences
O Leo, M Foo, DH Sachs, LE Samelson, JA Bluestone
Proceedings of the National Academy of Sciences, 1987•National Acad SciencesA monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by
immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific
for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts
with all mature T cells and can both activate and inhibit T-cell function. These results identify
T3-epsilon as a cell surface protein involved in the transduction of activation signals.
immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific
for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts
with all mature T cells and can both activate and inhibit T-cell function. These results identify
T3-epsilon as a cell surface protein involved in the transduction of activation signals.
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.
National Acad Sciences