[26] Electron microscopy of negatively stained lipoproteins

TM Forte, RW Nordhausen - Methods in enzymology, 1986 - Elsevier
Publisher Summary Negative staining is extremely useful in examining small
macromolecular structures and, specifically, does not require interaction between the stain
and the specimen. This chapter discusses the principle and application of electron
microscopy of negatively stained lipoproteins. Negative staining is extremely useful for the
examination of smaller, more dense lipoproteins, such as low-density lipoproteins (LDL) and
high-density lipoproteins (HDL). The chapter also presents criteria for an ideal negative stain …