[HTML][HTML] Phosphatidylinositol 3-kinase in interleukin 1 signaling: physical interaction with the interleukin 1 receptor and requirement in NFκB and AP-1 activation
SAG Reddy, JH Huang, WSL Liao - Journal of Biological Chemistry, 1997 - ASBMB
The signaling mechanisms utilized by the proinflammatory cytokine interleukin-1 (IL-1) to
activate the transcription factors NFκB and activator protein-1 (AP-1) are poorly defined. We
present evidence here that IL-1 not only stimulates a dramatic increase in
phosphatidylinositol 3-kinase (PI 3-kinase) activity but also induces the physical interaction
of its type I receptor with the p85 regulatory subunit of PI 3-kinase. Furthermore, two PI 3-
kinase-specific inhibitors, wortmannin and a dominant-negative mutant of the p85 subunit …
activate the transcription factors NFκB and activator protein-1 (AP-1) are poorly defined. We
present evidence here that IL-1 not only stimulates a dramatic increase in
phosphatidylinositol 3-kinase (PI 3-kinase) activity but also induces the physical interaction
of its type I receptor with the p85 regulatory subunit of PI 3-kinase. Furthermore, two PI 3-
kinase-specific inhibitors, wortmannin and a dominant-negative mutant of the p85 subunit …