[HTML][HTML] Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from …
C Leeuwenburgh, JE Rasmussen, FF Hsu… - Journal of Biological …, 1997 - ASBMB
Lipoprotein oxidation has been implicated in the pathogenesis of atherosclerosis. However,
the physiologically relevant pathways mediating oxidative damage have not yet been
identified. Three potential mechanisms are tyrosyl radical, hydroxyl radical, and redox active
metal ions. Tyrosyl radical forms o, o′-dityrosine cross-links in proteins. The highly reactive
hydroxyl radical oxidizes phenylalanine residues to o-tyrosine and m-tyrosine. Metal ions
oxidize low density lipoprotein (LDL) by poorly understood pathways. To explore the …
the physiologically relevant pathways mediating oxidative damage have not yet been
identified. Three potential mechanisms are tyrosyl radical, hydroxyl radical, and redox active
metal ions. Tyrosyl radical forms o, o′-dityrosine cross-links in proteins. The highly reactive
hydroxyl radical oxidizes phenylalanine residues to o-tyrosine and m-tyrosine. Metal ions
oxidize low density lipoprotein (LDL) by poorly understood pathways. To explore the …