Oxidation of low density lipoprotein leads to particle aggregation and altered macrophage recognition.

HF Hoff, TE Whitaker, J O'Neil - Journal of Biological Chemistry, 1992 - ASBMB
Oxidized (ox-) low density lipoproteins (LDL) is characterized by the formation of lipid
peroxides and their decomposition to reactive aldehydes which covalently link to apoB in
LDL. These chemical changes are believed to be responsible for the enhanced recognition
of ox-LDL by receptors on macrophages in culture. When oxidation is extensive, particle
aggregation also occurs. The aim of this study was to characterize aggregation formation
and how this influences the interaction of ox-LDL with macrophages in culture. When LDL …