The complete cDNA and amino acid sequence of human apolipoprotein B-100.

SH Chen, CY Yang, PF Chen, D Setzer… - Journal of Biological …, 1986 - ASBMB
We have determined the complete sequence of apolipoprotein (apo) B-100 cDNA. It is 14.1
kilobases in length and codes for a 4563-amino acid protein, including a 27-amino acid
signal peptide and a 4536-amino acid mature protein. Further, we identified 2366 residues
of apoB-100 by direct sequence analysis of apoB-100 tryptic peptides. The mature peptide is
characterized by high hydrophobicity (0.916 kcal/residue) and predicted beta-sheet content
(21%). Dot matrix analysis revealed the presence of many long internal repeats in apoB …