[HTML][HTML] Relative chlorinating, nitrating, and oxidizing capabilities of neutrophils determined with phagocytosable probes

Q Jiang, JK Hurst - Journal of Biological Chemistry, 1997 - ASBMB
The capabilities of stimulated neutrophils to initiate intraphagosomal and extracellular
chlorination, nitration, and other oxidative reactions has been evaluated using a fluorescent
particle and soluble phenolic compounds as target molecules. Neutrophils activated by the
soluble stimulus, phorbol myristate acetate, both chlorinated fluorescein that was covalently
attached to polyacrylamide microspheres and initiated tyrosine dimerization. When nitrite ion
was present at millimolar concentration levels in the medium, nitration of the phenolic rings …