Role of oxidatively modified LDL in atherosclerosis

UP Steinbrecher, H Zhang, M Lougheed - Free Radical Biology and …, 1990 - Elsevier
UP Steinbrecher, H Zhang, M Lougheed
Free Radical Biology and Medicine, 1990Elsevier
Oxidative modification of LDL is accompanied by a number of compositional and structural
changes, including increased electrophoretic mobility, increased density, fragmentation of
apolipoprotein B, hydrolysis of phosphatidylcholine, derivatization of lysine amino groups,
and generation of lfuorescent adducts due to covalent binding of lipid oxidation products to
apo B. In addition, oxidation of LDL has been shown to result in numerous changes in its
biologic properties that could have pathogenetic imortance, including accelerated uptake in …
Abstract
Oxidative modification of LDL is accompanied by a number of compositional and structural changes, including increased electrophoretic mobility, increased density, fragmentation of apolipoprotein B, hydrolysis of phosphatidylcholine, derivatization of lysine amino groups, and generation of lfuorescent adducts due to covalent binding of lipid oxidation products to apo B. In addition, oxidation of LDL has been shown to result in numerous changes in its biologic properties that could have pathogenetic imortance, including accelerated uptake in macrophages, cytotoxicity, and chemotactic activity for monocytes. The present article summarrizes very recent developments related to the mechanism of oxidation of LDL by cells, receptor-mediated uptake of oxidized LDL in macrophages, the mechanism of phosphatidylcholine hydrolysis during LDL oxidation, and other biologic actions of oxidized LDL including cytotoxicity, altered eicosanoid metabolism, and effects on the secretion of growth factors and chemotactic factors. In addition, this review will exzmine the evidence for the presence of oxidized LDL in vivo and the evidence that oxidized LDL plays a pathogenetic role in atherosclerosis.
Elsevier