Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension

DB Badesch, EC Orton, LM Zapp… - Am J Respir Cell Mol …, 1989 - atsjournals.org
DB Badesch, EC Orton, LM Zapp, JY Westcott, J Hester, NF Voelkel, KR Stenmark
Am J Respir Cell Mol Biol, 1989atsjournals.org
Prostaglandins have potent effects on vascular tone in both the systemic and the pulmonary
circulation. A connection between altered prostaglandin production and chronic vascular
disease has been suggested by previous studies in both experimental animal models and
humans. Meyrick and colleagues showed that inhibition of prostaglandin synthesis by
chronic administration of indomethacin induced significant pulmonary hypertension and
alterations of lung vessel morphology in sheep (1). Atherosclerotic vessels, tested in vitro,
Prostaglandins have potent effects on vascular tone in both the systemic and the pulmonary circulation. A connection between altered prostaglandin production and chronic vascular disease has been suggested by previous studies in both experimental animal models and humans. Meyrick and colleagues showed that inhibition of prostaglandin synthesis by chronic administration of indomethacin induced significant pulmonary hypertension and alterations of lung vessel morphology in sheep (1). Atherosclerotic vessels, tested in vitro,
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