Thymocytes stimulate metabolism of arachidonic acid in rat thymic epithelial cells
L Sun, AS Piltch, P Liu, LA Johnson, J Hayashi - Cellular immunology, 1990 - Elsevier
Arachidonic acid metabolites play an important role in the development of T cells in the
thymus. In the normal animal, prostaglandin levels in the thymus are significantly higher than
in plasma. Herein, we have studied the regulation of arachidonic acid metabolism using the
thymic endocrine epithelial cell line, TEA3A1, and thymocytes. We have found that TEA3A1
cells, but not thymocytes, produced prostaglandins and thromboxanes. We have also found
that thymocytes could stimulate the production of arachidonic acid metabolites in TEA3A1 …
thymus. In the normal animal, prostaglandin levels in the thymus are significantly higher than
in plasma. Herein, we have studied the regulation of arachidonic acid metabolism using the
thymic endocrine epithelial cell line, TEA3A1, and thymocytes. We have found that TEA3A1
cells, but not thymocytes, produced prostaglandins and thromboxanes. We have also found
that thymocytes could stimulate the production of arachidonic acid metabolites in TEA3A1 …