[HTML][HTML] Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in …
DA Gordon, H Jamil, RE Gregg, SO Olofsson… - Journal of Biological …, 1996 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and
chylomicrons. Evidence indicates that the subclasses of these lipoproteins that contain apoB-
48 are assembled in a distinct two-step process; first a relatively lipid-poor primordial
lipoprotein precursor is produced, and then bulk neutral lipids are added to form the core of
these spherical particles. To determine if either step is mediated by MTP, a series of clonal …
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and
chylomicrons. Evidence indicates that the subclasses of these lipoproteins that contain apoB-
48 are assembled in a distinct two-step process; first a relatively lipid-poor primordial
lipoprotein precursor is produced, and then bulk neutral lipids are added to form the core of
these spherical particles. To determine if either step is mediated by MTP, a series of clonal …