Interleukin 1 receptor on fibroblasts from systemic sclerosis patients induces excessive functional responses to interleukin 1β
Y Kawaguchi, M Harigai, K Suzuki, M Hara… - Biochemical and …, 1993 - Elsevier
Y Kawaguchi, M Harigai, K Suzuki, M Hara, K Kobayashi, T Ishizuka, Y Matsuki, N Tanaka…
Biochemical and biophysical research communications, 1993•ElsevierTo determine if SSc fibroblasts are more sensitive to exogenous IL-1 than are normal
fibroblasts, we studied the inductions of IL-6, prostaglandin E 2 (PGE 2), IL-1β mRNA
production by IL-1-stimulated SSc and normal fibroblasts. The minimal IL-1β concentrations
for stimulation of IL-6 and PGE 2 production by SSc fibroblasts were 10-fold and 100-fold
lower, respectively, than those for normal fibroblasts. The minimal IL-1β concentration for
stimulation of IL-1β mRNA expression by SSc fibroblasts was also 10-fold lower than that for …
fibroblasts, we studied the inductions of IL-6, prostaglandin E 2 (PGE 2), IL-1β mRNA
production by IL-1-stimulated SSc and normal fibroblasts. The minimal IL-1β concentrations
for stimulation of IL-6 and PGE 2 production by SSc fibroblasts were 10-fold and 100-fold
lower, respectively, than those for normal fibroblasts. The minimal IL-1β concentration for
stimulation of IL-1β mRNA expression by SSc fibroblasts was also 10-fold lower than that for …
Abstract
To determine if SSc fibroblasts are more sensitive to exogenous IL-1 than are normal fibroblasts, we studied the inductions of IL-6, prostaglandin E2 (PGE2), IL-1β mRNA production by IL-1-stimulated SSc and normal fibroblasts. The minimal IL-1β concentrations for stimulation of IL-6 and PGE2 production by SSc fibroblasts were 10-fold and 100-fold lower, respectively, than those for normal fibroblasts. The minimal IL-1β concentration for stimulation of IL-1β mRNA expression by SSc fibroblasts was also 10-fold lower than that for normal fibroblasts. These results suggest that the IL-1 signal transduction through IL-1R could be induced excessively in SSc fibroblasts. It is suggested that the IL-1 signal transduction plays an important role in the abnormal cytokine networks observed in the fibrosis of SSc.
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