[HTML][HTML] Lipoproteins are substrates for human secretory group IIA phospholipase A2: preferential hydrolysis of acute phase HDL
W Pruzanski, E Stefanski, FC de Beer, MC de Beer… - Journal of lipid …, 1998 - ASBMB
Group IIA secretory phospholipase A 2 is an acute phase enzyme, co-expressed with serum
amyloid A protein. Both are present in atherosclerotic lesions. We report that human normal
and acute phase high density lipoproteins and low density lipoprotein are effective
substrates for human group IIA phospholipase A 2. The enzyme hydrolyzed choline and
ethanolamine glycerophospholipids at the sn-2 position resulting in an accumulation of the
corresponding lysophospholipids, including the unhydrolyzed alkyl and alkenyl ether …
amyloid A protein. Both are present in atherosclerotic lesions. We report that human normal
and acute phase high density lipoproteins and low density lipoprotein are effective
substrates for human group IIA phospholipase A 2. The enzyme hydrolyzed choline and
ethanolamine glycerophospholipids at the sn-2 position resulting in an accumulation of the
corresponding lysophospholipids, including the unhydrolyzed alkyl and alkenyl ether …