Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apo AI from HDL and subsequent formation of discoidal HDL
MA Clay, HH Newnham, TM Forte, PI Barter - Biochimica et Biophysica Acta …, 1992 - Elsevier
The effects of lipid transfers and hepatic lipase (HL) on the concentration, composition,
particle size distribution and morphology of high density lipoproteins (HDL) have been
investigated. Human plasma supplemented with additional very low density lipoproteins
(VLDL), cholesteryl ester transfer protein (CETP) and HL has been incubated at 37° C for up
to 8 h. The HDL became depleted of cholesteryl esters and reduced in particle size. Within 2
h of such incubation they had also lost about 30% of their apo AI. However, with extension of …
particle size distribution and morphology of high density lipoproteins (HDL) have been
investigated. Human plasma supplemented with additional very low density lipoproteins
(VLDL), cholesteryl ester transfer protein (CETP) and HL has been incubated at 37° C for up
to 8 h. The HDL became depleted of cholesteryl esters and reduced in particle size. Within 2
h of such incubation they had also lost about 30% of their apo AI. However, with extension of …