Apolipoprotein AI metabolism in cholesteryl ester transfer protein transgenic mice. Insights into the mechanisms responsible for low plasma high density lipoprotein …
GW Melchior, CK Castle, RW Murray, WL Blake… - Journal of Biological …, 1994 - ASBMB
Expression of simian cholesteryl ester transfer protein (CETP) in C57BL/6 mice causes the
animals' high density lipoprotein (HDL) levels to decrease. The purpose of these studies
was to determine how CETP expression caused that reduction. Chemical analysis showed
that the HDL of the CETP transgenic mice had about twice as much triglyceride and only
about 60% as much cholesteryl ester as the HDL from the C57BL/6 mice. Both strains of
mouse had high levels of a circulating lipase. When plasma from the mice was incubated at …
animals' high density lipoprotein (HDL) levels to decrease. The purpose of these studies
was to determine how CETP expression caused that reduction. Chemical analysis showed
that the HDL of the CETP transgenic mice had about twice as much triglyceride and only
about 60% as much cholesteryl ester as the HDL from the C57BL/6 mice. Both strains of
mouse had high levels of a circulating lipase. When plasma from the mice was incubated at …