[HTML][HTML] Analysis of particle size and lipid composition as determinants of the metabolic clearance of human high density lipoproteins in a rabbit model
B Lamarche, KD Uffelman, G Steiner, PHR Barrett… - Journal of lipid …, 1998 - ASBMB
Hypertriglyceridemia is commonly associated with triglyceride (TG) enrichment of high
density lipoprotein (HDL) and reduction in HDL cholesterol and apolipoprotein AI levels. We
have recently reported that lipolytic modification of TG-rich HDL, which reduces particle size,
enhances its clearance from the circulation. In the present study, we examined the role of
particle size and lipid composition in determining the metabolic clearance of human HDL, in
the absence of substantial in vivo modification of the particle by hepatic lipase. The rabbit …
density lipoprotein (HDL) and reduction in HDL cholesterol and apolipoprotein AI levels. We
have recently reported that lipolytic modification of TG-rich HDL, which reduces particle size,
enhances its clearance from the circulation. In the present study, we examined the role of
particle size and lipid composition in determining the metabolic clearance of human HDL, in
the absence of substantial in vivo modification of the particle by hepatic lipase. The rabbit …