prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.
MJ Smyth, DK Perry, J Zhang, GG Poirier… - Biochemical …, 1996 - ncbi.nlm.nih.gov
Biochemical Journal, 1996•ncbi.nlm.nih.gov
The novel lipid second messenger, ceramide, specifically induced poly (ADP-ribose)
polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2
inhibited ceramide-induced poly (ADP-ribose) polymerase proteolysis and protected cells
from ceramide-induced death. These data provide the first insight into the mechanism by
which ceramide mediates apoptosis and suggest a mechanism by which Bel-2 protects from
cell death.
polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2
inhibited ceramide-induced poly (ADP-ribose) polymerase proteolysis and protected cells
from ceramide-induced death. These data provide the first insight into the mechanism by
which ceramide mediates apoptosis and suggest a mechanism by which Bel-2 protects from
cell death.
Abstract
The novel lipid second messenger, ceramide, specifically induced poly (ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly (ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bel-2 protects from cell death.
ncbi.nlm.nih.gov