A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the …
Y Inoue, N Nakamura, T Inagami - Journal of hypertension, 1997 - journals.lww.com
Y Inoue, N Nakamura, T Inagami
Journal of hypertension, 1997•journals.lww.comObjective To seek the mechanism whereby agonists, competitive antagonists and
insurmountable antagonists affect the receptor function differently, by reviewing recent
mutagenesis studies of angiotensin II type 1 receptor (AT 1) in which the binding of the
agonist and antagonists and receptor signaling were affected. AT1 receptor structure and
ligand binding sites We built a model of seven transmembrane spanning domains of the AT
1 receptors using bacteriorhodopsin as a template. The carboxy terminal of angiotensin II …
insurmountable antagonists affect the receptor function differently, by reviewing recent
mutagenesis studies of angiotensin II type 1 receptor (AT 1) in which the binding of the
agonist and antagonists and receptor signaling were affected. AT1 receptor structure and
ligand binding sites We built a model of seven transmembrane spanning domains of the AT
1 receptors using bacteriorhodopsin as a template. The carboxy terminal of angiotensin II …
Objective To seek the mechanism whereby agonists, competitive antagonists and insurmountable antagonists affect the receptor function differently, by reviewing recent mutagenesis studies of angiotensin II type 1 receptor (AT 1) in which the binding of the agonist and antagonists and receptor signaling were affected.
AT1 receptor structure and ligand binding sites We built a model of seven transmembrane spanning domains of the AT 1 receptors using bacteriorhodopsin as a template. The carboxy terminal of angiotensin II binds to Lys 199 in transmembrane domain 5, whereas the guanidinium group of Arg 2 binds to Asp 281 in transmembrane domain 7. Results of studies using mutagenesis supporting proposed ligand-docking models are discussed.
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