Association of insulin receptor substrate-1 with integrins
K Vuori, E Ruoslahti - Science, 1994 - science.org
K Vuori, E Ruoslahti
Science, 1994•science.orgInsulin stimulation was found to promote association of the αvβ3 integrin (a vitronectin
receptor) with insulin receptor substrate-1 (IRS-1), an intracellular protein that mediates
insulin signaling by binding other signaling molecules, including growth factor receptor-
bound protein 2 (Grb2) and phosphatidylinositol-3′ kinase. Insulin-treated cells expressing
the αvβ3 integrin showed 2.5 times more DNA synthesis when plated on vitronectin than on
other substrates, whereas cells expressing another vitronectin receptor, αvβ5, did not show …
receptor) with insulin receptor substrate-1 (IRS-1), an intracellular protein that mediates
insulin signaling by binding other signaling molecules, including growth factor receptor-
bound protein 2 (Grb2) and phosphatidylinositol-3′ kinase. Insulin-treated cells expressing
the αvβ3 integrin showed 2.5 times more DNA synthesis when plated on vitronectin than on
other substrates, whereas cells expressing another vitronectin receptor, αvβ5, did not show …
Insulin stimulation was found to promote association of the αvβ3 integrin (a vitronectin receptor) with insulin receptor substrate-1 (IRS-1), an intracellular protein that mediates insulin signaling by binding other signaling molecules, including growth factor receptor-bound protein 2 (Grb2) and phosphatidylinositol-3′ kinase. Insulin-treated cells expressing the αvβ3 integrin showed 2.5 times more DNA synthesis when plated on vitronectin than on other substrates, whereas cells expressing another vitronectin receptor, αvβ5, did not show this difference. The association between integrin and IRS-1 may be a mechanism for the synergistic action of growth factor and extracellular matrix receptors.
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